Publications
Publications in peer-reviewed international scientific journals. * author from the Department of Anaesthesiology, Intensive Care Medicine, Emergency Medicine and Pain Medicine, University of Turku and Turku University Hospital.
2010
Biancari F, Myllylä M, Lepojärvi S, Kuttila K, Porela P, *Laitio T, Ylitalo A, Jokinen V, Luokkala A, Airaksinen KEJ. Preoperative warfarin treatment and outcome of coronary artery bypass graft surgery. Ann Thorac Surg 2010:89(4):1139-1145.
Breivik H, *Jalonen J, Vigfússon G, Alahuhta S, Lagerkranser M. Nordic guidelines for neuraxial blocks in disturbed haemostasis from the Scandinavian society of anaesthesiologyand intensive care medicine. Acta Anaesthesiol Scand 2010:54:16-41.
*Grönlund J, *Saari T, *Hagelberg N, Martikainen IK, Neuvonen PJ, *Olkkola KT, Laine K. Effect of telithromycin on the pharmacokinetics and pharmacodynamics of oral oxycodone. J Clin Pharmacol 2010:50:101-108.
*Grönlund J, *Saari TI, *Hagelberg NM, Neuvonen PJ, *Olkkola KT, Laine K. Exposure to oral oxycodone in increased by concomitant inhibition of CYP2D6 and 3A4 pathways, but not by inhibition of CYP2D6 alone. Br J Clin Pharmacol 2010:70(1):78-87.
*Hagelberg NM. Social work in a pain clinic. Editorial. Scan J Pain 2010:1(4):211-212.
*Hagelberg NM, *Olkkola KT. Fentanyl for breakthrough cancer pain - what´s new? Pain 2010:151:565-566.
*Hagelberg NM, *Peltoniemi MA, *Saari TI, Kurkinen KJ, Laine K, Neuvonen PJ, *Olkkola KT. Clarithromycin, a potent inhibitor of CYP3A, greatly increases exposure to oral S-ketamine. Eur J Pain 2010:14:625-629.
Halme P, Antila J, *Antila H, Aho H, Polo O, Salminiitty H, Toskala E. Uvulopalatopharyngoplasty with an ultrasound scalpel or laser: is there a difference? Eur Arch Otorhinolaryngol 2010:267:635-642.
Heinonen I, Kemppainen J, *Kaskinoro K, Peltonen JE, Borra R, Lindroos MM, Oikonen V, Nuutila P, Knuuti J, Hellsten Y, Boushel R, Kalliokoski KK, *Kaskinoro K. Comparison of exogenous adenosine and voluntary exercise on human skeletal muscle perfusion and perfusion heterogeneity . J Appl Physiol 2010:108:378-386.
Heinonen IH, Kemppainen J, *Kaskinoro K, Peltonen JE, Borra R, Lindroos M, Oikonen V, Nuutila P, Knuuti J, Boushel R, Kalliokoski KK. Regulation of human skeletal muscle perfusion and its heterogeneity during exercise in moderate hypoxia. Am J Physiol Regul Integr Comp Physiol 2010:299:R72-R79.
*Iirola T, *Laitio R, *Kentala E, *Aantaa R, Kurvinen J-P, Scheinin M, *Olkkola KT. Highly variable pharmacokinetics of dexmedetomidine during intensive care: a case report. J Med Case Reports (Online: http://jmedicalcasereports.com/home) 2010:73(4).
*Illman H, *Antila H, *Olkkola KT. Reversal of neuromuscular blockade by sugammadex does not affect eeg derived indices of depth of anesthesia. J Clin Monit Comp 2010:24:371-376.
*Illman HL, *Antila H MJ, *Olkkola KT. Effect of nitrous oxide on cisatracurium infusion demands: a randomized controlled trial. BMC Anesthesiol 2010:10:14.
*Karanko MS, Helttula IO, Klemi PJ, Gullichsen EA. Arterial oxygenation can fall critically during intramedullary nailing of pathological femoral fractures. J Trauma. Injury Infect Crit Care 2010:69(5):1210-1216.
*Kaskinoro K, *Maksimow A, Scheinin H, *Laitio R, *Aantaa R, Kärki T, Jääskeläinen S, Hinkka-Yli-Salomäki S. Normobaric hyperoxia does not induce significant electroencephalogram changes in healthy male subjects. Internet J Neuromonitoring 2010:6(1).
Klemetti S, Kinnunen I, Suominen T, *Antila H, Vahlberg T, Grenman R, Leino-Kilpi H. The effect of preoperative nutritional face-to-face counseling about child`s fasting on parental knowledge, preoperative need-for-information, and anxiety, in pediatric ambulatory tonsillectomy. Patient Educ Couns 2010:80(1):64-70.
Klemetti S, Kinnunen I, Suominen T, *Antila H, Vahlberg T, Grenman R, Leino-Kilpi H. The effect of preoperative fasting on postoperative thirst, hunger and oral intake in paediatric ambulatory tonsillectomy. J Clin Nurs 2010:19:341-350.
Klemetti S, Kinnunen I, Suominen T, *Antila H, Vahlberg T, Grenman R, Leino-Kilpi H. Active preoperative nutrition is safely implemented by the parents in pediatric ambulatory tonsillectomy. Ambul Surg 2010:16(3):75-79.
*Leino K.A., *Kuusniemi K.S., Pälve H.K., Korpelainen J.T., Tiusanen H.T., *Tuppurainen T.T. Spread of spinal block in patients with rheumatoid arthritis. Acta Anaesthesiol Scand 2010:54:65-69.
Luostarinen T, *Takala RSK, Niemi TT, *Katila A J, Niemelä M, Hernesniemi J, Randell T. Adenosine-induced cardiac arrest during intraoperative cerebral aneurysm rupture. World Neurosurg 2010:73(2):79-83.
*Nieminen TH, *Hagelberg NM, *Saari TI, *Neuvonen M, Laine K, Neuvonen PJ, *Olkkola KT. St John`s wort greatly reduces the concentrations of oral oxycodone. Eur J Pain 2010:14:854-859.
*Nieminen TH, *Hagelberg NM, *Saari TI, Neuvonen M, Neuvonen PJ, Laine K, *Olkkola KT. Oxycodone concentrations are greatly increased by the concomitant use of ritonavir or lopinavir/ritonavir . Eur J Clin Pharmacol 2010:66:977-985.
*Nieminen TH, *Hagerberg NM, *Saari TI, Neuvonen M, Neuvonen PJ, Laine K. Grapefruit juice enhances the exposure to oral oxycodone. Basic Clin Pharmacol Toxicol 2010:107(4):782-788.
*Olkkola KT, *Hagelberg NM. Investigation of drug-drug interactions and pain - From volunteer studies to randomized controlled trials in patients with chronic pain. Scan J Pain 2010:1:5.
Ryynänen O-P, *Iirola T, Reitala J, Pälve H, Malmivaara A. Is advanced life support better than basic life support in prehospital care? A systematic review. Scand J Trauma Resusc Emerg Med 2010:18:62.
*Saari TI, *Grönlund J, *Hagelberg NM, Neuvonen M, Laine K, Neuvonen PJ, *Olkkola KT. Effects of itraconazole on the pharmacokinetics and pharmacodynamics of intravenously and orally administered oxycodone. Eur J Clin Pharmacol 2010:66:387-397.
*Saari TI, *Olkkola KT. Azole antimycotics and drug interactions in the perioperative period. Editorial. Curr Opin Anaesthesiol 2010:23:441-448.
*Siirala W, *Olkkola KT, Noponen T, *Vuori A, *Aantaa R. Predictive equations over-estimate the resting energy expenditure in amyotrophic lateral sclerosis patients who are dependent on invasive ventilation support. Nutr Metab (Lond) 2010:7: 70.
*Tommila M, Stark C, Jokilammi A, Peltonen V, Penttinen R, Ekholm E. Hemoglobin expression in rat experimental granulation tissue. J Mol Cell Biol 2010.
Varis J, *Kuusniemi K, Järveläinen H. Cholesterol microembolization syndrome: a complication of anticoagulant therapy. Can Med Assoc J 2010:182(9):931-933.
2009
Aalto S, Hirvonen J, Kaasinen V,* Hagelberg N, Kajander J, Någren K, Seppälä T, Rinne JO, Scheinin H, Hietala J. The effects of d-amphetamine on extrastriatal dopamine D2/D3 receptors: a randomized, double-blind, placebo-controlled, PET study with1C-FLB45in heatlhy subjects. Eur J Nucl Med Mol Imaging 2009:36:475-483.
Eriksson HI, *Jalonen JR, Heikkinen LO, Kivikko M, Laine M, *Leino KA, Kuitunen AH, Kuttila KT, Peräkylä TK, Sarapohja T, Suojaranta-Ylinen RT, *Valtonen M, Salmenperä MT. Levosimendan facilitates weaning from cardiopulmonary bypass in patients undergoing coronary artery bypass grafting with impaired left ventricular function. Ann Thorac Surg 2009:87:448-454.
Falkenbach P, Kämäräinen A, Mäkelä A, Kurola J, Varpula T, Ala-Kokko T, *Perttilä J, Tenhunen J. Incidence of iatrogenic dyscarbia during mild therapeutic hypothermia after successful resuscitation from out-of-hospital cardiac arrest. Resuscitation2 2009:80:990-993.
*Hagelberg NM, *Nieminen TH, *Saari TI, Neuvonen M, Neuvonen PJ, Laine K, *Olkkola KT. Voriconazole drastically increases exposure to oral oxycodone. Eur J Pharmacol 2009:65:263-271.
*Hynninen VV, *Olkkola KT, Bertilsson L, Kurkinen KJ, Korhonen T, Neuvonen PJ, Laine K. Voriconazole increases while itraconazole decreases plasma meloxicam concentrations. Antimicrob Agents Chemother 2009:53(2):587-592.
*Hynninen VV, *Olkkola KT, Neuvonen PJ, Laine K. Oral voriconazole and miconazole oral gel produce comparable effects on the pharmacokinetics and pharmacodynamics of etoricoxib. Eur J Pharmacol 2009:65:89-95.
Klemetti S, Kinnunen I, Suominen T, *Antila H, Vahlberg T, Grenman R, Leino-Kilpi H. The effects of preoperative fasting on postoperative pain, nausea and vomiting in pediatric ambulatory tonsillectomy. Int J Pediatr Otorhinolaryngol 2009:73:263-273.
Lindroos MM, Majamaa K, Tura A, Mari A, Kalliokoski KK, *Taittonen MT, Iozzo P, Nuutila P. m.3243A>G mutation in mitochondrial DNA leads to decreased insulin sensitivity in skeletal muscle and to progressive beta-cell dysfunction . Diabetes (NY) 2009:58:543-549.
Linko R, Okkonen M, Pettilä V, *Perttilä J, Parviainen I, Ruokonen E, Tenhunen J, Ala-Kokko T, Varpula T, The FINNALI-study group. Acute respiratory failure in intensive care units. FINNALI: a prospective cohort study. Intensive Care Med 2009:35:1352-1361.
Luostarinen T, *Takala R S K, Niemi TT, *Katila A J, Niemelä M, Hernesniemi J, Randell T. Adenosine-induced cardiac arrest during intraoperative cerebral aneurysm rupture. Surg Neurol 2009.
Martikainen IK, Hirvonen J, Pesonen U, *Hagelberg N, Laurikainen H, Tuikkala H, Kajander J, Någren K, Hietala J, Pertovaara A. Differential associations between brain-HT1A receptor binding and response to pain versus touch. J Neural Transm 2009:116:821-830.
*Merivirta R, *Kuusniemi K, *Jaakkola P, *Pihlajamäki K, Pitkänen M. Unilateral spinal anaesthesia for outpatient surgery: a comparison between hyperbaric bupivacaine and bupivacaine-clonidine combination. Acta Anaesthesiol Scand 2009:53:788-793.
*Nieminen TH, *Hagelberg NM, *Saari TI, Pertovaara A, Neuvonen M, Laine K, Neuvonen PJ, *Olkkola KT. Rifampicin greatly reduces the plasma concentrations of intravenous and oral oxycodone. Anesthesiology 2009:110(6):1371-1378.
*Olkkola KT, *Hagelberg NM. Oxycodone: new 'old' drug. Curr Opin Anaesthesiol 2009:22:459-462.
Potts AL, Anderson BJ, Warman GR, Lerman J, Diaz SM, *Vilo S. Dexmedetomidine pharmacokinetics in pediatric intensive care - a pooled analysis. Paediatr Anaesth 2009:19:1119-1129.
Pudas-Tähkä S-M, Axelin A, *Aantaa R, Lund V, Salanterä S. Pain assessment tools for unconscious or sedated intensive care patients: a systematic review. J Adv Nurs 2009:65(5):946-956.
Snapir A, Talke P, Posti J, Huiku M, *Kentala E, Scheinin M. Effects of nitric oxide synthase inhibition on dexmedetomidine-induced vasoconstriction in healthy human volunteers. Br J Anaesth 2009:102(1):38-46.
*Takala RSK, Karjalainen V-M, *Salo MS, Kirvelä O, Kääpä P, Riutta A, *Aantaa R. Pulmonary inflammatory mediators after sevoflurane anaesthesia in tobacco smoking and non-smoking patients. The Open Information Journal 2009;2:1-8.
*Tommila M, Jokilammi A, Terho P, Wilson T, Penttinen R, Ekholm E. Hydroxyapatite coating of cellulose sponges attracts bone-marrow-derived stem cells in rat subcutaneous tissue. Journal of the Royal Society Interface 2009:6:73-880.
Viljanen APM, Karmi A, Borra R, Pärkkä JP, Lepomäki V, Parkkola R, Lautamäki R, Järvisalo M, *Taittonen M, Rönnemaa T, Iozzo P, Knuuti J, Nuutila P, Raitakari OT. Effect of caloric restriction on myocardial fatty acid uptake, left ventricular mass, and cardiac work in obese adults. Am J Cardiol 2009:103:1721-1726.
Virtanen KA, Lidell ME, Orava J, Heglind M, Westergren R, Niemi T, *Taittonen M, Laine J, Savisto N-J, Enerbäck S, Nuutila P. Functional brown adipose tissue in healthy adults. N Engl J Med 2009:360:1518-1525.
2008
Ahonen J, Aranko K, Iivanainen A, Maunuksela E-L, Paloheimo M, *Olkkola KT. Parmacokinetic-pharmacodynamic relationship of dobutamine and heart rate, stroke volume and cardiac output in healthy volunteers. Clin Drug Invest 2008:28(2):121-127.
Hamunen K, Maunuksela E-L, *Olkkola KT. Interpretation of the large red-and-white visual analog scale by children compared with adults. J Pediatr Nurs 2008:23(2):142-144.
Hirvonen J, Aalto S,*Hagelberg N, *Maksimow A, Ingman K, Oikonen V, Virkkala J, Någren K, *Scheinin H. Measurement of central my-opioid receptor binding in vivo with PET and [11C]carfentanil: a test-retest study in healthy subjects. EUROPEAN JOURNAL NUCLEAR MEDICIN MOL IMAGING 2008.
Huupponen E, *Maksimow A, Lapinlampi P, Särkelä M, Saastamoinen A, Snapir A, *Scheinin H, Scheinin M, Meriläinen P, Himanen S-L, Jääskeläinen S. Electroencephalogram spindle activity during dexmedetomidine sedation and physiological sleep. Acta Anaesthesiol Scand 2008:52:289-294.
*Hynninen V-V, *Olkkola KT, Bertilsson L, Kurkinen K, Neuvonen PJ, Laine K. Effect of terbinafine and voriconazole on the pharmacokinetics of the antidepressant venlafaxine. Clin Pharmacol Ther 2008:83(2):342-348.
*Illman H, *Antila H, *Olkkola KT. Quantitation of the effect of nitrous oxide on rocuronium infusion requirements using closed-loop feedback control. Anesthesiology 2008:108(3):388-391.
Karvonen S, Salomäki T, *Olkkola KT. Efficacy of oral paracetamol and ketoprofen for pain management after major orthopedic surgery. Methods Find Exp Clin Pharmacol 2008:30(9):703-706.
*Laitio RM, *Kaskinoro K, Särkelä MO, *Kaisti KK , Salmi E, *Maksimov A, *Långsjö J W, *Aantaa R, Kangas K, Jääskeläinen S, *Sheinin H. Bispectral index entropy, and quantitative electroencephalogram during single-agent xenon anesthesia. Anesthesiology 2008:108(1):63-70.
*Liukas A, *Kuusniemi K, *Aantaa R, Virolainen P, Neuvonen M, Neuvonen PJ, *Olkkola KT. Plasma concentrations of oral oxycodone are greatly increased in the elderly. Clin Pharmacol Ther 2008:84(4):462-467.
*Olkkola K T, Ahonen J. Midazolam and other benzodiazepines. In: Schuttler J, Schwilden H, eds. Modern Anesthetics. Handbook of experimental pharmacology 182, p. 335-360. Berlin Heidelberg 2008: Springer-Verlag,2008.
POISE Study Group (including *Leino K). Effects of extended-release metoprolol succinate in patients undergoing non-cardiac surgery (POISE trial): a randomised controlled trial. Lancet 2008:371(31):1839-1846.
Randell T, *Antila H. Developments in laryngoscopy and tracheal intubation: videogames and practical tools. Acta Anaesthesiol Scand 2008:52:3-5.
*Saari TI, Laine K, Neuvonen M, Neuvonen PJ, *Olkkola KT. Effect of voriconazole and fluconazole on the pharmacokinetics of intravenous fentanyl. Eur J Clin Pharmacol 2008:64(1):25-30.
*Salmi E, Aalto S, Hirvonen J, *Långsjö JW, Maksimow AT, Oikonen V, Metsähonkala L, Virkkala J, Någren K, *Scheinin H. Measurement of GABAA receptor binding in vivo with (11C)flumazenil: A test-retest study in healthy subjects. Neuroimage 2008:41:260-269.
Salmi E, *Laitio RM, Aalto S, *Maksimow AT, *Långsjö JW, *Kaisti KK, *Aantaa R, Oikonen V, Metsähonkala L, Någren K, Korpi ER, *Scheinin H. Xenon does not affect gamma-aminobutyric acid type A receptor binding in humans. Anesth Analg 2008:106(1):129-134.
*Vilo S, Rautiainen P, *Kaisti K, *Aantaa R, Scheinin M, *Manner T, *Olkkola KT. Pharmacokinetics of intravenous dexmedetomidine in children under 11 yr of age. Br J Anaesth 2008:100(5):697-700.
Virkkunen I, Paasio L, Ryynänen S, *Vuori A, Sajantila A, Yli-Hankala A, Silfvast T. Pulseless electrical activity and unsuccessful out-of-hospital resuscitation: What is the cause of death? Resuscitation 2008;77(2):207-10.
2007
Asola M, Virtanen K, Någren K, Helin S, *Taittonen M, Kastarinen H, Anderstam B, Knuuti J, Metsärinne K, Nuutila P. Amino-acid-based peritoneal dialysis solution improves amino-acid transport into skeletal muscle. Kidney Int 2007:00:1-6.
Handolin L, *Elomaa T. The Finnish Forward Surgical Team experience during EUFOR operation RD Congo in 2006. Eur J Trauma Emerg Surg 2007(3):245-250.
Heinonen I, Nesterov SV, Kemppainen J, Nuutila P, Knuuti J, *Laitio R, Kjaer M, Boushel R, Kalliokoski KK. Role of adenosine in regulating the heterogeneity of skeletal muscle blood flow during exercise in humans. J Appl Physiol 2007:103:2042-2048.
Hynninen V-V, Olkkola KT, *Leino K, Lundgren S, Neuvonen PJ, Rane A, *Valtonen M, Laine K. Effect of voriconazole on the pharmacokinetics of diclofenac. Fund Clin Pharmacol 2007:21:651-656.
Jokinen MJ, Neuvonen PJ, Lindgren L, Höckerstedt K, Sjövall J, Breuer O, Askemark Y, Ahonen J, Olkkola KT. Pharmacokinetics of ropivacaine in patients with chronic end-stage liver disease. Anesthesiology 2007:106:43-55.
Kroigaard M, Garvey LH, Gillberg L, Johansson SGO, Mosbech H, Florvaag E, Harboe T, Eriksson LI, Dahlgren G, Seeman-Lodding H, *Takala R, Wattwil M, Hirlekar G, Dahlén B, Guttormsen AB. Scandinavian Clinical Practice Guidelines on the diagnosis, management and follow-up of anaphylaxis during anaesthesia. Acta Anaesthesiol Scand 2007:51:655-670.
Laitio RM, *Kaisti KK, Långsjö JW, Aalto S, *Salmi E, *Maksimow A, Aantaa R, Oikonen V, Sipilä H, Parkkola R, Scheinin H. Effects of xenon anesthesia on cerebral blood flow in humans: a positron emission tomography study . Anesthesiology 2007:6(106):1128-1133.
Laitio T, Jalonen J, Kuusela T, Scheinin H. The role of heart rate variability in risk stratification for adverse postoperative cardiac events. Anesth Analg 2007:105(6):1548-1560.
Maksimow A, Snapir A, Särkelä M, Kentala E, Koskenvuo J, Posti J, Jääskeläinen SK, Hinkka-Yli-Salomäki S, Scheinin M, Scheinin H. Assessing the depth of dexmedetomidine-induced sedation with electroencephalogram (EEG)-based spectral entropy. Acta Anaesthesiol Scand 2007:51:22-30.
Martikainen IK, Hirvonen J, Kajander J,*Hagelberg N, Mansikka H, Någren K, Hietala J, Pertovaara A. Correlation of human cold pressor pain responses with 5-HT 1A receptor binding in the brain. Brain Res 2007:1172:21-31.
Mäenpää M, Penttilä J, *Laitio T,*Kaisti K, Kuusela T, Hinkka S, Scheinin H. The effects of surgical levels of sevoflurane and propofol anaesthesia on heart rate variability. Eur J Anaesthesiol 2007:24:626-633. Kustannusosakeyhtiö Medicina , 2007.
Saari T.Effects of cytochrome P450 enzyme inhibitors on the metabolism of drugs used in anaesthesiology. Doctoral dissertation. 2007. Annales Universitatis Turkuensis. Series D. 99p. p.[a] 2007:40(4):356.
Saari TI, Laine K, Bertilsson L, Neuvonen PJ, Olkkola KT. Voriconazole and fluconazole increase the exposure to oral diazepam. Eur J Clin Pharmacol 2007:63:941-949.
Saari TI, Laine K,*Leino K,*Valtonen M, Neuvonen PJ,Olkkola KT. Effect of voriconazole on the pharmacokinetics and pharmacodynamics of zolpidem in healthy subjects. Br J Clin Pharmacol 2007:63:116-120.
Silvanto M, Munsterhjelm E, Savolainen S, Tiainen P, Niemi T, Ylikorkala O, *Scheinin H, *Olkkola KT. Effect of 3 g of intravenous paracetamol on post-operative analgesia, platelet function and liver enzymes in patients undergoing tonsillectomy under local anaesthesia. Acta Anaesthesiol Scand 2007:51:1147-1154.
Virkkunen I, Ryynänen S, Kujala S,*Vuori A, Piilonen A, Kääriä J-P, Pettilä V, Yli-Hankala A, Silfvast T. Incidence of regurgitation and pulmonary aspiration of gastric contents in survivors from out-of-hospital cardiac arrest. Acta Anaesthesiol Scand 2007:51:202-205.
2006
*Aantaa R, *Jalonen J. Perioperative use of alpha2-adrenoceptor agonists and the cardiac patient. Eur J Anaesthesiol 2006:23:361-372.
*Antila H, *Manner T, Kuurila K, Salanterä S, Kujala R, *Aantaa R. Ketoprofen and tramadol for analgesia during early recovery after tonsillectomy in children. Paediatr Anaesth 2006.
Helttula I, *Karanko M, Gullichsen E. Similar central hemodynamics but increased postoperative oxygen consumption in unreamed versus reamed intramedullary nailing of femoral fractures. J Trauma. Injury Infect Crit Care 2006:61(5):1178-1185.
*Hynninen V-V, *Olkkola KT, *Leino K, Lundgren S, Neuvonen PJ, Rane A, *Valtonen M, Vyyryläinen H, Laine K. Effects of the antifungals voriconazole and fluconazole on the pharmacokinetics of S-(+)- and R-(-)-ibuprofen. Antimicrob Agents Chemother 2006:50(6):1967-1972.
Isohanni M H, Neuvonen P J, *Olkkola K T. Effect of fluvoxamine and erythromycin on the pharmacokinetics of oral lidocaine. Basic Clin Pharmacol Toxicol 2006:99:168-172.
*Laitio TT, Huikuri HV, Koskenvuo J, *Jalonen J, Mäkikallio TH, Helenius H, *Kentala ESH, Hartiala J. Long-term alterations of heart rate dynamics after coronary artery bypass graft surgery. Anesth Analg 2006:102:1026-1031.
POISE Trial Investigators (incl. *Jalonen J, *Leino K). Rationale, design, and organization of the perioperative ischemic evaluation (POISE) trial: a randomized controlled trial of metoprolol versus placebo in patients undergoing noncardiac surgery. Am Heart J. 2006 Aug;152(2):223-30.
Maksimow A, Snapir A, Särkelä E, *Kentala E, Koskenvuo J, Posti J, Jääskeläinen SK, Hinkka-Yli-Salomäki S, Scheinin M, *Scheinin H. Assessing the depth of dexmededetomidine-induced swdation with electroencephalogram (EEG)-based spectral entropy. Acta Anaesthesiol Scand 2006(51):22-30.
Maksimow A, Särkelä M, *Långsjö J, Salmi E, *Kaisti K, Yli-Hankala A, Hinkka-Yli-Salomäki S, *Scheinin H, Jääskeläinen S. Increase in high frequency EEG activity explains the poor performance of EEG spectral entropy monitor during S-ketamine anesthesia. Clin Neurophysiol 2006:117:1660-1668.
Nikkola E, Läärä A, Hinkka S, Ekblad U, Kero P,*Salonen M. Patient-controlled epidural analgesia in labor does not always improve maternal satisfaction. Acta Obstet Gynecol Scand 2006:85:188-194.
Nussmeier N A, Whelton A A, Brown M T, Joshi G P, Langford R M, Singla N K, Boye M E, Verburg K M. and Participating Investigators (incl. *Jalonen J). Safety and efficacy of the cyclooxygenase-2 inhibitors parecoxib and valdecoxib after noncardiac surgery. Anesthesiology 2006:104(3):518-26.
*Olkkola K T. Anesthetic drug interactions. In: Hemmings H C, Hopkins P M, eds. Foundations of Anesthesia, p. 119-127. Philadelphia: Mosby Elsevier, 2006.
Penttilä J, Snapir A, *Kentala E, Koskenvuo J, Scheinin M, *Scheinin H, Kuusela T, Posti J. Estimation of cardiac output in a pharmacological trial using a simple method based on arterial blood pressure signal waveform: a comparison with pulmonary thermodilution and echocardiographic methods. Eur J Clin Pharmacol 2006:62:401-407.
Rovasalo A, Tohmo H, *Aantaa R, Kettunen E, Palojoki R. Dexmedetomidine as an adjuvant in the treatment of alcohol withdrawal delirium: a case report. Gen Hosp Psych 2006:28:362-363.
*Saari T I, Laine K, *Leino K, *Valtonen M, Neuvonen P J, *Olkkola K T. Voriconazole, but not terbinafine, markedly reduces alfentanil clearance and prolongs its half-life. Clin Pharmacol Ther 2006:80:502-8.
*Saari TI, Laine K, *Leino K, *Valtonen M, Neuvonen PJ, *Olkkola KT. Effect of voriconazole on the pharmacokinetics and pharmacodynamics of intravenous and oral midazolam. Clin Pharmacol Ther 2006:79:362-370.
Schrey AR, Aitasalo KMJ, Kinnunen IAJ, Laaksonen MS, Parkkola RK,*Taittonen MT, Grénman RA, Minn HRI. Functional evaluation of microvascular free flaps with positron emission tomography. JOURNAL OF PLASTIC, RECONSTRUCTIVE & AESTHETIC SURGERY 2006:59:158-165.
Sell A, *Olkkola K T, *Jalonen J, *Aantaa R. Isobaric bupivacaine via spinal catheter for hip replacement surgery: ED50 and ED95 dose determination. Acta Anaesthesiol Scand 2006:50:217-221.
Snapir A, Posti J, *Kentala E, Koskenvuo J, Sundell J, Tuunanen H, Hakala K, Knuuti J, Scheinin M. Effects of low and high plasma concentrations of dexmedetomidine on myocardial perfusion and cardiac function in healthy male subjects. Anesthesiology 2006:105(5):902-909.
*Takala R S K, *Katila A J, Sonninen P, *Perttilä J. Panhypopituitarism after traumatic head injury. NEUROCRITICAL CARE 2006:4(1):21-24.
*Takala RSK, Soukka H, *Salo MS, Kirvelä O, Kääpä P, *Aantaa R. Gene expression of pulmonary cytokines after sevoflurane or thiopentone anaesthesia in pigs. Acta Anaesthesiol Scand 2006:50:163-167.
Virkkunen I, Kujala S, Ryynänen S, *Vuori A, Pettilä V, Yli-Hankala A, Silfvast T. Bystander mouth-to-mouth ventilation and regurgitation during cardiopulmonary resuscitation. J Intern Med 2006:260:39-42.
2005
Ingman K, *Hagelberg N, Aalto S, Någren K, Juhakoski A, Karhuvaara S, Kallio A, Oikonen V, Hietala J, *Scheinin H. Prolonged central mu-opioid receptor occupancy after single and repeated nalmefene dosing. Neuropsychopharmacology 2005:1-9.
Isohanni MH, Ahonen J, Neuvonen PJ, *Olkkola KT. Effect of ciprofloxacin onthe pharmacokinetics of intravenous lidocaine. Eur J Anaesthesiol2005:22:795-799.
Kanto D, Salo M, Happonen R-P, Vahlberg T, *Kanto J. Tramadol premedicationin operative extraction of the mandibular third molar: aplacebo-controlled crossover study. Acta Odontol Scand 2005:63:43-49.
Kanto D, Vanhamäki M, Kössi L, *Salo M, Karjalainen S. Pain and anxiety control in the dental care of intellectually disabled institutionalizedpatients.
Kyllönen M, *Olkkola KT, Seppälä T, Ryhänen P. Perioperative pharmacokinetics of ibuprofen enantiomers after rectal administration. Paediatr Anaesth 2005:15:566-573.
*Laitio T, Kuusela T, Huikuri H, *Jalonen J, *Kentala E, Mäkikallio T, Helenius H, Pullisaar O, Hartiala J, *Scheinin H. Reply (to Prediction of postoperative myocardial ischemia by fractal heart rate dynamics). Anesth Analg 2005:100(1):289-290.
*Lund VE, *Kentala E, *Scheinin H, Lertola K, *Klossner J, Aitasalo K, Sariola-Heinonen K, *Jalonen J. Effect of age and repeated hyberbaric oxygen treatments on vagal tone. Undersea Hyperb Med 2005:32(2):111-119.
Lähteenmäki M, *Salo M, Tenovuo J, Vahlberg T. Effects of anaesthesia using endotracheal intubation or the laryngeal mask airway, or spinal anaesthesia, on oral mucosal host defences during minor surgery. Acta Anaesthesiol Scand 2005:49:1318-1325.
*Långsjö J W, Maksimow A, Salmi E, *Kaisti K, Aalto S, Oikonen V, Hinkka S, *Aantaa R, Sipilä H, Viljanen T, Parkkola R, *Scheinin H. S-ketamine anesthesia increases cerebral blood flow in excess of the metabolic needs in humans. Anesthesiology 2005:103(2):258-268.
Maksimow A, *Kaisti K, Aalto S, Mäenpää M, Jääskeläinen S, Hinkka S, Martens S, Särkelä M, Viertiö-Oja H, *Scheinin H. Correlation of EEG spectral entropy with regional cerebral blood flow during sevoflurane and propofol anaesthesia. Anaesthesia 2005:60:862-869.
Martikainen IK, *Hagelberg N, *Mansikka H, Hietala J, Någren K, *Scheinin H, Pertovaara A. Association of striatal dopamine D2/D3 receptor binding potential with pain but not tactile sensitivity or placebo analgesia. Neurosci Lett 2005:376:149-153. [C]
*Olkkola KT, Isohanni MH, Hamunen K, Neuvonen PJ. The effect of erythromycin and fluvoxamine on the pharmacokinetics of intravenous lidocaine. Anesth Analg 2005:100:1352-1356.
Penttilä J, Mäenpää M, *Laitio T, *Långsjö J, Hinkka S, *Scheinin H. Subanaesthetic doses of ketamine impair cardiac parasympathetic regulation. Eur J Anaesthesiol 2005:22:808-810.
Pokela M-L, Anttila E, Seppälä T, *Olkkola KT. Marked variation in oxycodone pharmacokinetics in infants. Paediatr Anaesth 2005:15:560-565.
Salmi E, *Långsjö J, Aalto S, Någren K, Metsähonkala L, *Kaisti K, Korpi E, Hietala J, *Scheinin H. Subanesthetic ketamine does not affect 11C-flumazenil binding in humans. Anesth Analg 2005:101:722-725.
Sell A, *Olkkola KT, *Jalonen J, *Aantaa R. Minimum effective local anaesthetic dose of isobaric levobupivacaine and ropivacaine administered via a spinal catheter for hip replacement surgery. Br J Anaesth 2005:94(2):239-242.
Tohmo H, *Antila H. Increase in the use of rebreathing gas flow systems and in the utilization of low fresh gas flows in Finnish anaesthetic practice from 1995 to 2002. Acta Anaesthesiol Scand 2005:49:328-330.
Vähäsilta T, Saraste A, Kytö V, Malmberg M, Kiss J, *Kentala E, Kallajoki M, Savunen T. Cardiomyocyte apoptosis after antegrade and retrograde cardioplegia. Ann Thorac Surg 2005:80:2229-2234.
2004
Antila S, Pesonen U, Lehtonen L, Tapanainen P, Nikkanen H, Vaahtera K, *Scheinin H. Pharmacokinetics of levosimendan and its active metabolite OR-1896 in rapid and slow acetylators. Eur J Pharm Sci 2004:23:213-222.
*Hagelberg N, Aalto S, Kajander J, Oikonen V, Hinkka S, Någren K, HietalaJ, *Scheinin H. Alfentanil increases cortical dopamine D2/D3 receptorbinding in healthy subjects. PAIN 2004:109:86-93.
*Hagelberg N, Jääskeläinen SK, Martikainen IK, *Mansikka H, Forssell H, *Scheinin H, Hietala J, Pertovaara A. Striatal dopamine D2 receptors inmodulation of pain in humans: a review. Eur J Pharmacol 2004:500:187-192.
Isohanni MH, Neuvonen PJ, *Olkkola KT. Effect of Itraconazole on thepharmacokinetics of inhaled lidocaine. BASIC & CLINICAL PHARMACOLOGY &TOXICOLOGY 2004:95:120-123.
*Kaisti KK, Mäkitalo J, Sipilä HT, Teräs MIP, *Scheinin H. Ventilator add-on for delivering PET tracer gases. J Nucl Med Technol 2004:32(2):79-82.
Laine K, De Bruyn S, Björklund H, Rouru J, Hänninen J, Scheinin H, Anttila M, *Scheinin H. Effect of the novel anxiolytic drug deramciclane on cytochrome P450 2D6 activity as measured by desipramine pharmacokinetics. Eur J Pharmacol 2004:59:893-898.
*Laitio TT, Huikuri HV, Mäkikallio TH, *Jalonen J, *Kentala ESH, Helenius H, Pullisaar O, Hartiala J, *Scheinin H. The breakdown of fractal heart rate dynamics predicts prolonged postoperative myocardial ischemia. Anesth Analg 2004:98:1239-1244.
*Långsjö JW, Salmi E, *Kaisti KK, Aalto S, Hinkka S, *Aantaa R, Oikonen V, Viljanen T,Kurki T, Silvanto M, *Scheinin H. Effects of subanesthetic ketamine on regional cerebral glucose metabolism in humans. Anesthesiology2004:100(5):1065-1071.
*Mansikka H, Lähdesmäki J, Scheinin M, Pertovaara A. Alpha2A Adrenoceptors contribute to feedback inhibition of capsaicin-induced hyperalgesia. Anesthesiology 2004:101:185-190.
*Mansikka H, Lähdesmäki J, Scheinin M, Pertovara A. alfa2A Adrenoceptors contribute to feedback inhibition of capsaicin-induced hyperalgesia. Anesthesiology 2004:101( 1):185-190.
*Mansikka H, Zhao C, Sheth RN, Sora I, Uhl G, Raja SN. Nerve injury induces a tonic bilateral my-opioid receptor-mediated inhibitory effect on mechanical allodynia in mice. Anesthesiology 2004:100(4):912-921.
Nikkola EM, *Leino KA, *Takala RSK, Kirvelä OA, *Salonen MAO. The validity of the static-charge-sensitive bed in the detection of fentanyl-induced respiratory depression. Acta Anaesthesiol Scand 2004:48:371-376.
Penttilä J, Helminen A, Anttila M, Hinkka S, *Scheinin H. Cardiovascular and parasympathetic effects of dexmedetomidine in healthy subjects. CANADIAN JOURNAL OF PHYSIOLOGICAL PHARMACOLOGY 2004:82:359-362.
Penttilä J, Kaila T, Helminen A, Anttila M, Karhuvaara S, Huhtala S, *Scheinin H. Effects of atipamezole - a selective a2-adrenoceptorantagonist - on cardiad parasympathetic regulation in human subjects. Auton Autacoid Pharmacol 2004:24:69-75.
Pertovaara A, Martikainen IK, *Hagelberg N, *Mansikka H, Någren K, HietalaJ, *Scheinin H. Striatal dopamine D2/D3 receptor availability correlates with individual response characteristics to pain. Eur J Neurosci 2004:20:1587-1592.
Pöyhiä R, Hynynen M, Seppälä T, Roine RO, Verkkala K, *Olkkola KT. Pharmacodynamics and pharmacokinetics of high-dose oxycodone infusion during and after coronary artery bypass grafting. J Cardiothorac Vasc Anesth 2004:18(6):748-754.
*Långsjö JW, Salmi E, *Kaisti KK, Metsähonkala L, Oikonen V, Aalto S, Någren K, HinkkaS, Hietala J, Korpi ER, *Scheinin H. Sevoflurane and propofol increase11C-flumazenil binding to gamma-aminobutyric acid A receptors in humans. Anesth Analg 2004:99:1420-1426.
*Takala RSK, Soukka HR, *Salo MS, *Kirvelä OA, Kääpä PO, Rajamäki AA, RiuttaA, *Aantaa RE, . Pulmonary inflammatory mediators after sevoflurane and thiopentone anaesthesia in pigs. Acta Anaesthesiol Scand 2004: (48):40- 45.
*Vuori A, *Salo M, Viljanto J, Pajulo O, Pulkki K, Nevalainen T, *Vuori A.Effects of post-operative pain treatment using non-steroidal anti-inflammatory analgesics, opioids or epidural blockade on systemic and local immune responses in children. Acta Anaesthesiol Scand 2004:48:738-749.
Özdogan ÜK, Lähdesmäki J, *Mansikka H, Scheinin M. Loss of amitriptyline analgesia in alpha2A-adrenoceptor deficient mice. Eur J Pharmacol 2004:485:193-196.
2003
*Hagelberg N, Forssell H, Rinne JO, *Scheinin H, Taiminen T, Aalto S, Luutonen S, Någren K, Jääskeläinen S. Striatal dopamine D1 and D2 receptors in burning mouth syndrome. PAIN 2003:101:149-154.
Lähdesmäki J, Scheinin M, Pertovaara A, *Mansikka H. The alpha2A-adrenoceptor subtype is not involved in inflammatory hyperalgesia or morphine-induced antinociception. Eur J Pharmacol 2003:468(3):183-189.
*Kirla RM, Haapasalo HK, Kalimo H, Salminen EK. Low expression of p27 indicates a poor prognosis in patients with high-grade astrocytomas. Cancer 2003:97(3):644-648.
*Tohmo H, *Pälve H, *Illman H. The work, duties and prestige of Finnish anesthesiologists: patients´ view. Acta Anaesthesiol Scand 2003:47:664-666.
*Kaisti K K, *Långsjö J W, Aalto S, Oikonen V, Sipilä H, Teräs M, Hinkka S, Metsähonkala L, *Scheinin H. Effects of sevoflurane, propofol, and adjunct nitrous oxide on regional cerebral blood flow, oxygen consumption, and blood volume in humans. Anesthesiology 2003:99(3):603-613.
Huupponen R, Paija O, *Salonen M, Björklund H, Rouru J, Anttila M. Pharmacokinetics of deramciclane, a novel anxiolytic agent, after intravenous and oral administration. Drugs R D 2003:4(6):339-345.
Hirvonen J, Aalto S, Lumme V, Någren K, Kajander J, Vilkman H, *Hagelberg N, Oikonen V, Hietala J. Measurement of striatal and thalamic dopamine D2 receptor binding with 11C-raclopride. Nucl Med Commun 2003:24:1207-1214.
*Långsjö J, *Kaisti K, Aalto S, Hinkka S, Aantaa R, Oikonen V, Sipilä H, Kurki T, Silvanto M, *Scheinin H. Effects of subanesthetic doses of ketamine on regional cerebral blood flow, oxygen consumption, and blood volume in humans. Anesthesiology 2003:99(3):614-623.
*Hagelberg N, Forssell H, Aalto S, Rinne JO, *Scheinin H, Taiminen T, Någren K, Eskola O, Jääskeläinen SK. Altered dopamine D2 receptor binding in atypical facial pain. PAIN 2003:106:43-48.
Jääskeläinen S, Kaisti K, Suni L, Hinkka S, *Scheinin H. Sevoflurane is epileptogenic in healthy subjects a surgical levels of anesthesia . Neurology 2003:61(8):1073-1078.
2002
*Hagelberg N, Kajander J K, Någren K, Hinkka S, Hietala J, *Scheinin H. mu-Receptor agonism with alfentanil increases striatal dopamine d2 receptor binding in man. Synapse 2002:45:25-30.
*Hagelberg N, Kajander J, Någren K, Hinkka S, Hietala J, *Scheinin H. u-receptor agonism with alfentanil increases striatal dopamine D2 receptor binding in man. Synapse 2002(45):25-30.
*Hagelberg N, Martikainen I, *Mansikka H, Hinkka S, Någren K, Hietala J, *Scheinin H, Pertovaara A. Dopamine D2 receptor binding in the human brain is associated with the response to painful stimulation and pain modulatory capacity. PAIN 2002:99:273-279.
*Iirola T, *Lund VE, *Katila A, *Mattila-vuori A, *Pälve H. Teaching hospital physicians´skills and knowledge of resuscitation algorithms are deficient. Acta Anaesthesiol Scand 2002:46:1150-1154.
*Jalonen J. Levosimendan in cardiac anaesthesia. ANAESTHESIOLOGY INTENSIVE THERAPY 2002:34:66C-67C.
*Kaisti K, Metsähonkala L, Teräs M, Oikonen V, Aalto S, Jääskeläinen S, Hinkka S, *Scheinin H. Effects of surgical levels of propofol and sevoflurance anesthesia on cerebral blood flow in healthy subjects studied with positron emission tomography. Anesthesiology 2002(96):1358-1370.
Karjalainen S, Vanhamäki M, Kanto D, Kössi L, *Salo M. Long-term physical inactivity and oral health in Finnish adults with intellectual disability. Acta Odontol Scand 2002:60:50-55.
*Laitio T, Mäkikallio T, Huikuri H, *Kentala E, Uotila P, *Jalonen J, Helenius H, Hartiala J, Yli-Mäyry S, *Scheinin H. Relation of heart rate dynamics to the occurence of myocardial ischemia after coronary artery bypass grafting. Am J Cardiol 2002:89:1176-1181.
*Mansikka H, Zhou L, Donovan M, Pertovaara A, Raja S N. The role of mu-opioid receptors in inflammatory hyperalgesia and alpha2-andrenoceptor-mediated antihyperalgesia. Neuroscience 2002:113(2):339-349.
Muhonen A, Muhonen J, Minn H, Kulmala J, *Klossner J, Teräs M, Knuuti J, Happonen R-P. The effects of irridation and hyberbaric oxygen on bone formation during rabbit mandibular distraction. Arch Oral Biol 2002(47):701-707.
Nikkola E, Kirjavainen T, Ekblad U, Kero P, *Salonen M. Postnatal adaptation after caesarean section or vaginal delivery, studied with the static-charge-sensitive bed. Acta Paediatr 2002:91:927-933.
Persson J, Hasselström J, Maurset A, Öye I, Svensson J-O, Almqvist O, *Scheinin H, Gustafsson LL, Almqvist O. Pharmacokinetics and non-analgesic effects of S- and R-ketamines in healthy volunteers with normal and reduced metabolic capacity. Eur J Clin Pharmacol 2002:57(12):869-875.
*Takala RSK, Soukka HR, Kirvelä OA, Kujari HP, Pelliniemi LJ, Kääpä PO, *Aantaa RE. Alveolar integrity and ultrastructure in pigs remain undamaged after exposure to sevoflurane. Acta Anaesthesiol Scand 2002:46:1137-1143.
*Tuppurainen T, Mäkinen J, *Salonen M. Reducing the risk of systemic embolization during gynecologic laparoscopy - effect of volume preload. Acta Anaesthesiol Scand 2002:46:37-42.